[Pilot study of coadjuvant treatment of recurrent cystitis in women by means of AM3 (Immnoferon)]

Actas Urol Esp. 2003 Mar;27(3):196-201. doi: 10.1016/s0210-4806(03)72905-2.
[Article in Spanish]

Abstract

Objectives: The aim is to evaluate the effectiveness of AM3 (Inmunoferon) in the treatment of the recurrent cystitis in women in order to know the rate of good results, previously to design a clinical trial.

Material and methods: Twenty-four women who had been diagnosed of two cystitis episodes in the previous 6 months without cure by antibiotic treatment were admitted to the study. Standard antibiotic treatment and 3 daily grammes of AM3 was given for 9 months. Infection and irritative symptoms during micturition rate were evaluated at the inclusion date and afterwards, at the first, third, sixth and nineth month.

Results: Nineteen patients finished the study. The infection rate decreased from 100% at the inclusion date to 26% in the first month and then it became stable about 50%. Irritative symptoms during micturition decreased from 46% at the inclusion date to a rate lower than 10% in the 4 controls running.

Conclusion: AM3 reduced evident urinary infection in a 50% and irritative symptoms during micturition in a 90%. Control clinical trials are needed to confirm the AM3 effects on this pathology.

Publication types

  • English Abstract

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Amoxicillin / therapeutic use
  • Calcium Phosphates / therapeutic use*
  • Ciprofloxacin / therapeutic use
  • Clavulanic Acid / therapeutic use
  • Cystitis / complications
  • Cystitis / drug therapy*
  • Cystitis / prevention & control
  • Drug Evaluation
  • Drug Therapy, Combination / therapeutic use
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / prevention & control
  • Female
  • Follow-Up Studies
  • Fosfomycin / therapeutic use
  • Glycopeptides / therapeutic use*
  • Humans
  • Pilot Projects
  • Recurrence
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Vaginosis, Bacterial / complications

Substances

  • Adjuvants, Immunologic
  • Calcium Phosphates
  • Glycopeptides
  • Clavulanic Acid
  • Fosfomycin
  • Ciprofloxacin
  • Amoxicillin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Immunoferon