This article uses case reviews to illustrate key clinical features of several important epilepsy subgroups: newly diagnosed patients with epilepsy, women of childbearing age with seizures, elderly patients who develop epilepsy, patients with developmental disabilities, and patients with medication-resistant epilepsy. Characteristic clinical features for these patients (seizure types, ages of seizure onset, and treatment responses) guide clinical evaluation, treatment selections, and monitoring for medication side effects and seizures.