Abstract
To investigate the route of zoonotic transmission of HIV-1, we isolated three and seven HIV-1 strains from 449 Pygmy hunter gatherers and 169 neighboring Bantu, respectively, in southern Cameroon. Phylogenetic analysis based on pol-integrase and env-C2V3 sequences revealed that strains from Pygmies were 1CRF02_AG/CRF02_AG, 1 subtype G/CRF02 AG (pol/env), and 1 CRFll_cpx/CRF11_cpx, and that those from Bantu were 2 CRF02_AG/CRF02_AG, 1 CRF02_AG/CRF01_AE/A, 1 CRF02_AG/subtype A, 1 G/A, 1G/CRF02_AG, and 1 unclassified fH. CRF02_AG and CRF11_cpx have been identified in Cameroon. The results suggest that HIV-1 has been introduced into Pygmies through their neighboring Bantu rather than directly from nonhuman primates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Animals
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Cameroon / ethnology
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Ethnicity
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Female
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Gene Products, env / genetics
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Gene Products, pol / genetics
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HIV Envelope Protein gp120 / genetics
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HIV Infections / ethnology*
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HIV Infections / transmission*
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HIV Infections / virology
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HIV Integrase / genetics
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HIV-1 / classification*
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HIV-1 / genetics*
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Native Hawaiian or Other Pacific Islander*
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Peptide Fragments / genetics
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Phylogeny
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Racial Groups
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Sequence Analysis, DNA
Substances
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Gene Products, env
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Gene Products, pol
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
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HIV Integrase
Associated data
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GENBANK/AY180111
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GENBANK/AY180112
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GENBANK/AY180113
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GENBANK/AY180114
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GENBANK/AY180115
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GENBANK/AY180116
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GENBANK/AY180117
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GENBANK/AY180118
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GENBANK/AY180119
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GENBANK/AY180120
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GENBANK/AY180121
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GENBANK/AY180122
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GENBANK/AY180123
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GENBANK/AY180124
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GENBANK/AY180125
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GENBANK/AY180126
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GENBANK/AY180127
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GENBANK/AY180128
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GENBANK/AY180129
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GENBANK/AY180130