Abstract
A series of novel 12-membered ring macrolides was designed based on available information on structure-activity relationships and macrolide-ribosome interactions. Compounds with the desosamine and the anchor group properly attached to the 12-membered lactone ring exhibited improved activity against erythromycin-resistant organisms.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial
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Erythromycin / pharmacology*
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Haemophilus influenzae / drug effects
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Microbial Sensitivity Tests
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Staphylococcus aureus / drug effects
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Streptococcus pyogenes / drug effects
Substances
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Anti-Bacterial Agents
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Erythromycin