Intercellular adhesion molecules and vascular cell adhesion molecule-1 and the kidney

J Am Soc Nephrol. 1992 Dec;3(6):1201-11. doi: 10.1681/ASN.V361201.

Abstract

Adhesion molecules such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are expressed in the kidney and are regulated by proinflammatory cytokines. These adhesion molecules play an important role in the binding and activation process of leukocytes and are of importance in inflammatory kidney diseases. This review article describes current knowledge regarding the structure, expression, and functional role of adhesion molecules and their significance in immune-mediated renal diseases.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / physiology*
  • Gene Expression Regulation
  • Humans
  • Intercellular Adhesion Molecule-1
  • Kidney / physiology*
  • Kidney Diseases / etiology
  • Vascular Cell Adhesion Molecule-1

Substances

  • Cell Adhesion Molecules
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1