Factors associated with oropharyngeal human immunodeficiency virus shedding

J Infect Dis. 2003 Jul 1;188(1):142-5. doi: 10.1086/375741. Epub 2003 Jun 23.

Abstract

Orogenital transmission of human immunodeficiency virus (HIV) is considered to be inefficient, and infectious HIV is rarely detected in saliva. To evaluate the posterior oropharynx as a source of HIV shedding, we studied 64 HIV-infected men who have sex with men in Seattle, Washington, and Lima, Peru. In multivariate analysis, receipt of antiretroviral therapy, higher CD4 cell count, and history of tonsillectomy were predictors of lower pharyngeal HIV RNA levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • HIV Infections / transmission
  • HIV-1 / genetics
  • HIV-1 / isolation & purification
  • HIV-1 / physiology*
  • Humans
  • Male
  • Middle Aged
  • Oropharynx / virology*
  • RNA, Viral / analysis
  • Virus Shedding*

Substances

  • RNA, Viral