Abstract
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Boron Compounds / chemical synthesis*
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Boron Compounds / pharmacology
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Cell Division / drug effects
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Chalcone / analogs & derivatives*
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Chalcone / chemical synthesis*
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Chalcone / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Nuclear Proteins*
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Proto-Oncogene Proteins / biosynthesis
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Proto-Oncogene Proteins c-mdm2
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Boron Compounds
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Nuclear Proteins
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Proto-Oncogene Proteins
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Chalcone
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2