Abstract
Callyspongamide A (1), a new cytotoxic polyacetylenic amide, has been isolated from the marine sponge Callyspongia fistularis collected in the Red Sea. Callyspongamide A is an amide derivative of a C(17)-polyacetylenic acid and phenethylamine. It represents a new class of secondary metabolites within the family Callyspongiidae. Its structure was determined on the basis of 1D and 2D (COSY, HOHAHA, HMQC, and HMBC) NMR studies and high-resolution mass spectral measurement.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylene / analogs & derivatives
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Acetylene / chemistry
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Acetylene / isolation & purification*
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Acetylene / pharmacology
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Alkynes
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Amides / chemistry
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Amides / isolation & purification*
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Amides / pharmacology
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells / drug effects
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Humans
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Indian Ocean
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polymers / chemistry
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Polymers / isolation & purification*
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Polymers / pharmacology
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Porifera / chemistry*
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Tumor Cells, Cultured / drug effects
Substances
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Alkynes
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Amides
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Antineoplastic Agents
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Polymers
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callyspongamide A
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Acetylene