Abstract
The aqueous extracts of Datura fastuosa leaves and seeds were evaluated for the analgesic effect on acetic acid-induced writhing and hot plate reaction in mice. According to the results, D. fastuosa leaves and seeds extracts at oral doses of 400 and 800 mg/kg are effective as analgesic. The analgesic activity of leaf extract is reduced by naloxone but not that of seed extract.
MeSH terms
-
Acetic Acid
-
Administration, Oral
-
Analgesics / administration & dosage
-
Analgesics / pharmacology*
-
Analgesics / therapeutic use
-
Animals
-
Datura*
-
Dose-Response Relationship, Drug
-
Hot Temperature
-
Mice
-
Pain / chemically induced
-
Pain / prevention & control*
-
Pain Measurement / drug effects
-
Phytotherapy*
-
Plant Extracts / administration & dosage
-
Plant Extracts / pharmacology*
-
Plant Extracts / therapeutic use
-
Plant Leaves
-
Seeds
Substances
-
Analgesics
-
Plant Extracts
-
Acetic Acid