Accuracy and precision of a point-of-care hemoglobinometer for measuring hemoglobin concentration and estimating packed cell volume in horses

J Am Vet Med Assoc. 2003 Jul 1;223(1):78-83. doi: 10.2460/javma.2003.223.78.

Abstract

Objective: To determine accuracy and precision of a point-of-care hemoglobinometer for measuring hemoglobin concentration and estimating PCV in horses.

Design: Prospective trial.

Animals: 55 horses.

Procedure: Blood samples were obtained from 43 horses examined at a veterinary teaching hospital. Hemoglobin concentration was measured with the hemoglobinometer and by means of the standard cyanmethemoglobin method; PCV was measured by centrifugation. Blood samples were also obtained from 12 healthy horses, and PCV of aliquots of these samples was altered to approximately 5 to 80% by removing or adding plasma. Hemoglobin concentration and PCV were then measured.

Results: For samples from the clinic patients, hemoglobin concentrations obtained with the hemoglobinometer were less than concentrations obtained with the cyanmethemoglobin method; however, there was a linear relationship between concentrations obtained with the 2 methods. Breed, sex, body weight, and duration of sample storage did not significantly affect the difference between hemoglobin concentrations obtained with the 2 methods. There was a significant linear relationship between PCV and hemoglobinometer hemoglobin concentration (PCV = [2.83 x hemoglobin concentration] - 0.62). For samples from the healthy horses, a substantial negative bias was evident with the hemoglobinometer when hemoglobin concentration exceeded 16 g/dL.

Conclusions and clinical relevance: Results suggest that this hemoglobinometer is reasonably accurate and precise when used to measure hemoglobin concentration in blood samples from horses with a hemoglobin concentration < 16 g/dL.

MeSH terms

  • Animals
  • Female
  • Hematocrit / veterinary*
  • Hematologic Diseases / blood
  • Hematologic Diseases / veterinary
  • Hemodilution
  • Hemoglobinometry / instrumentation
  • Hemoglobinometry / methods
  • Hemoglobinometry / veterinary*
  • Hemoglobins / analysis*
  • Horse Diseases / blood
  • Horses / blood*
  • Male
  • Methemoglobin / analogs & derivatives*
  • Methemoglobin / analysis
  • Prospective Studies
  • Regression Analysis
  • Sensitivity and Specificity

Substances

  • Hemoglobins
  • cyanomethemoglobin
  • Methemoglobin