Abstract
The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate,and benzodiazepine. Two cases of hypothermia occurred after combining the use of zotepine, valproate, and benzodiazepine. The valproate was under therapeutic blood level when zotepine dosage was raised to 200 mg/day, and hypothermia occurred. The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Anxiety Agents / adverse effects
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Anticonvulsants / adverse effects
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Antipsychotic Agents / administration & dosage*
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Antipsychotic Agents / adverse effects*
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Bipolar Disorder / complications
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Bipolar Disorder / drug therapy
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Diazepam / adverse effects
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Dibenzothiepins / administration & dosage*
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Dibenzothiepins / adverse effects*
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Drug Interactions
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Drug Therapy, Combination
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Humans
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Hypothermia / chemically induced*
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Hypothermia / physiopathology
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Male
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Schizophrenia / complications
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Schizophrenia / drug therapy
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Valproic Acid / adverse effects
Substances
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Anti-Anxiety Agents
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Anticonvulsants
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Antipsychotic Agents
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Dibenzothiepins
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Valproic Acid
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Diazepam
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zotepine