Cobalt-mediated approach for the synthesis of terpene-based hybrids

Org Lett. 2003 Jul 10;5(14):2381-4. doi: 10.1021/ol034483y.

Abstract

[structure: see text] Dicobalt-beta-pinene hybrids of types I and II have been prepared using a Nicholas reaction between propargyl derivatives, obtained from commercial (1R)-(-)-myrtenal, and different aromatic nucleophiles. The method is suitable for the preparation of densely functionalized bio-organometallic natural product-based hybrids, as demonstrated by the preparation of a beta-pinene-neoclerodane hybrid.