Abstract
HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis / immunology
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology
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Embryo Implantation / immunology
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Endothelium, Vascular / immunology
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Female
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Genes, MHC Class I
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HLA Antigens / chemistry
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HLA Antigens / genetics
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HLA Antigens / metabolism*
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HLA-G Antigens
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / genetics
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Histocompatibility Antigens Class I / metabolism*
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Humans
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Maternal-Fetal Exchange / immunology*
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Models, Immunological
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Placenta / immunology
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Pregnancy
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Promoter Regions, Genetic
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Protein Isoforms / chemistry
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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Solubility
Substances
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I
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Protein Isoforms