Abstract
We describe a 57-year-old woman who underwent modified mastectomy for right breast cancer (T2N0M0) with overexpression of HER2, in whom lung metastasis developed 3 years after operation. She received sequential chemotherapy, including epirubicin plus cyclophosphamide, docetaxel, paclitaxel and trastuzumab, but the lung lesion progressed after transiently showing a partial response. Oral treatment with UFT and cyclophosphamide was begun as fifth-line treatment. The lung tumor shrank after 2 months, and a partial response has been maintained during continued treatment with UFT and cyclophosphamide. No adverse effects have occurred. We regard combination therapy with oral UFT and cyclophosphamide to be useful for the management of metastatic breast cancer, even in heavily pretreated cases with overexpression of HER2.
MeSH terms
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal, Humanized
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Bridged-Ring Compounds / administration & dosage
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Cyclophosphamide / administration & dosage
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Drug Combinations
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Epirubicin / administration & dosage
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Female
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Humans
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / secondary*
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Mastectomy, Segmental
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Middle Aged
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Receptor, ErbB-2 / biosynthesis*
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Taxoids*
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Tegafur / administration & dosage
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Trastuzumab
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Uracil / administration & dosage
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Bridged-Ring Compounds
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Drug Combinations
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Taxoids
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UFT(R) drug
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Tegafur
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taxane
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Epirubicin
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Uracil
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Cyclophosphamide
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Receptor, ErbB-2
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Trastuzumab