Abstract
A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval between Gas2 and Herc2 on mouse Chromosome 7 (Chr 7). Luzp2 is normally expressed only in brain and spinal cord. The human homolog of Luzp2 maps to Chr 11p13-11p14 by radiation-hybrid mapping and is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Disruption of Luzp2 by gene targeting in mice did not result in any obvious abnormal phenotypes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Chromosome Deletion
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Chromosome Mapping*
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Chromosomes, Human, Pair 11 / genetics*
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Cloning, Molecular
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DNA Mutational Analysis
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DNA Primers / chemistry
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / isolation & purification
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DNA-Binding Proteins / metabolism
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Female
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Gene Expression Regulation, Developmental
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Gene Targeting
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Humans
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Leucine Zippers / genetics*
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Molecular Sequence Data
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Phenotype
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Polymerase Chain Reaction
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Radiation Hybrid Mapping
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Ribonuclease, Pancreatic / metabolism
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Tumor Cells, Cultured
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WAGR Syndrome / genetics
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WAGR Syndrome / metabolism
Substances
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DNA Primers
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DNA-Binding Proteins
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LUZP2 protein, human
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Luzp2 protein, mouse
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Ribonuclease, Pancreatic