Abstract
Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditsioside E treatment resulted in a prominent increase of the G 2 /M population in HL-60 cells, and an accumulation of the sub-G 1 (hypoploid) peak was observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Cell Cycle / drug effects*
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Flow Cytometry
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Fruit
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Gleditsia*
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HL-60 Cells / drug effects
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Humans
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Inhibitory Concentration 50
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Paclitaxel / pharmacology
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Phytotherapy*
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Plant Extracts / pharmacology*
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Saponins / pharmacology*
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Saponins
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gleditsioside E
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Paclitaxel