Abstract
We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Anxiety Agents / pharmacology*
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Anti-Anxiety Agents / therapeutic use
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Antidepressive Agents / pharmacology*
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Antidepressive Agents / therapeutic use
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Cyclopentanes / pharmacology*
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Cyclopentanes / therapeutic use
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Dose-Response Relationship, Drug
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Hippocampus / drug effects
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Male
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Rats
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Rats, Wistar
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Receptors, Metabotropic Glutamate / agonists*
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Tricarboxylic Acids / pharmacology*
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Tricarboxylic Acids / therapeutic use
Substances
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1-aminocyclopentane-1,2,4-tricarboxylic acid
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Anti-Anxiety Agents
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Antidepressive Agents
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Cyclopentanes
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Receptors, Metabotropic Glutamate
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Tricarboxylic Acids
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metabotropic glutamate receptor 3