Abstract
Novel constrained beta-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Substitution*
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Dipeptides / chemical synthesis
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Enkephalin, Leucine / analogs & derivatives*
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Enkephalin, Leucine / chemical synthesis*
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Molecular Mimicry*
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Protein Structure, Secondary
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Stereoisomerism
Substances
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Dipeptides
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Enkephalin, Leucine