Abstract
Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticholesteremic Agents / chemical synthesis*
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Anticholesteremic Agents / pharmacology
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Body Weight
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Cholesterol / blood
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Cholesterol, Dietary / administration & dosage
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Ethers / chemical synthesis
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Ethers / pharmacology
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Hesperidin / chemical synthesis
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Hesperidin / chemistry*
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Hesperidin / pharmacology
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Hypercholesterolemia / blood
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Hypercholesterolemia / drug therapy
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Mice
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Structure-Activity Relationship
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Time Factors
Substances
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Anticholesteremic Agents
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Cholesterol, Dietary
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Ethers
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hesperetin 7-O-lauryl ether
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hesperetin 7-O-oleyl ether
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Cholesterol
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Hesperidin
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hesperetin