Abstract
We tested the hypothesis that, in heart transplant recipients, plasma aminoterminal pro-brain natriuretic peptide (NT-proBNP) dosage is useful for diagnosis of high ventricular loading pressures in the absence of systolic dysfunction. We studied 60 consecutive transplanted heart recipients without systolic dysfunction at 1 to 16 years after transplantation. We found that, in these patients with frequent high ventricular filling pressures, plasma NT-proBNP was highly correlated with creatininemia and not correlated with ventricular loading pressures. These results do not support the hypothesis that NT-proBNP is useful for diagnosis of isolated diastolic dysfunction in transplanted heart recipients.
Publication types
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Comparative Study
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Evaluation Study
MeSH terms
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Adult
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Aged
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Biomarkers / blood
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Creatinine / blood
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Creatinine / urine
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Female
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Heart Failure / blood
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Heart Failure / physiopathology
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Heart Failure / therapy
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Heart Transplantation*
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Humans
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Immunosuppressive Agents / therapeutic use
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Male
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Middle Aged
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Natriuretic Peptide, Brain
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Nerve Tissue Proteins / blood*
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Peptide Fragments / blood*
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Postoperative Complications / blood
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Postoperative Complications / etiology
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Postoperative Complications / physiopathology
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Prospective Studies
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Protein Precursors / blood*
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Statistics as Topic
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Stroke Volume / drug effects
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Stroke Volume / physiology
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Treatment Outcome
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Ventricular Dysfunction, Left / blood
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Ventricular Dysfunction, Left / physiopathology
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Ventricular Dysfunction, Left / therapy
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Ventricular Pressure / physiology*
Substances
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Biomarkers
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Immunosuppressive Agents
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Nerve Tissue Proteins
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Peptide Fragments
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Protein Precursors
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pro-brain natriuretic peptide (1-76)
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Natriuretic Peptide, Brain
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Creatinine