Abstract
Esters of N,N-diethylaminoacetic acid and hydroxyamines, obtained from structurally different natural monoterpenes, were pharmacologically examined. It was proved that salts of the obtained compounds had local anesthetic properties in infiltration anesthesia, compounds 9, 6 and 8 having been more potent than lidocaine. Compounds 7-9 slightly increased the arrhythmogenic dose, and compound 12 - the lethal dose of strophanthin. All the examined compounds transiently decreased the arterial blood pressure and displayed a cardiopressive activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthetics, Local / chemical synthesis*
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Anesthetics, Local / pharmacology
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Anesthetics, Local / toxicity
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Animals
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Anti-Arrhythmia Agents / chemical synthesis
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Anti-Arrhythmia Agents / pharmacology
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Anti-Arrhythmia Agents / toxicity
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / prevention & control
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Blood Pressure / drug effects
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Cardiovascular Agents / chemical synthesis*
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Cardiovascular Agents / pharmacology
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Cardiovascular Agents / toxicity
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Chromatography, Gas
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Chromatography, Thin Layer
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Guinea Pigs
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Heart / drug effects
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Hydroxylamines / chemical synthesis*
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Hydroxylamines / pharmacology
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Hydroxylamines / toxicity
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In Vitro Techniques
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Lethal Dose 50
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Male
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Mice
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Rats
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Rats, Wistar
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Terpenes / chemical synthesis*
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Terpenes / pharmacology
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Terpenes / toxicity
Substances
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Anesthetics, Local
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Anti-Arrhythmia Agents
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Cardiovascular Agents
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Hydroxylamines
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Terpenes