CCR5 mimicry by sulfated human anti-HIV-1 antibodies

Cell. 2003 Jul 25;114(2):147-8. doi: 10.1016/s0092-8674(03)00564-6.

Abstract

HIV-1 envelope glycoprotein interaction with a principal coreceptor, CCR5, requires sulfated tyrosines on the CCR5 amino terminus. In this issue of Cell, Choe et al. identified tyrosine-sulfated, neutralizing antibodies against HIV-1 that apparently mimic CCR5. The results demonstrate for the first time that a natural posttranslational modification of an antibody can contribute substantially to antigen recognition.

Publication types

  • Comment

MeSH terms

  • Antibodies, Monoclonal / metabolism
  • CD4 Antigens / metabolism
  • HIV Antibodies / metabolism*
  • HIV Envelope Protein gp120 / metabolism
  • HIV-1 / immunology*
  • Humans
  • Molecular Mimicry*
  • Peptides / metabolism
  • Protein Processing, Post-Translational
  • Receptors, CCR5 / chemistry
  • Receptors, CCR5 / metabolism*
  • Sulfates / metabolism*
  • Tyrosine / metabolism

Substances

  • Antibodies, Monoclonal
  • CD4 Antigens
  • HIV Antibodies
  • HIV Envelope Protein gp120
  • Peptides
  • Receptors, CCR5
  • Sulfates
  • Tyrosine