Abstract
Effects of amikacin, gentamicin, kanamycin, and streptomycin on renal tissue superoxide dismutase, glutathione peroxidase, glutathione and malondialdehyde, serum creatinine, potassium, sodium, total protein, glucose, uric acid, and total bilirubin levels were investigated. All aminoglycoside antibiotics decreased renal tissue glutathione levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / pharmacology*
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Animals
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / metabolism*
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Bilirubin / blood
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Blood Glucose / analysis
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Blood Proteins / analysis
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Creatinine / blood
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Glutathione Peroxidase / metabolism
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Kidney / drug effects*
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Kidney / enzymology
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Kidney / metabolism
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Male
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Malondialdehyde / metabolism*
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Mice
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Mice, Inbred BALB C
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Potassium / blood
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Random Allocation
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Sodium / blood
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Superoxide Dismutase / metabolism
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Uric Acid / blood
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Antioxidants
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Blood Glucose
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Blood Proteins
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Uric Acid
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Malondialdehyde
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Sodium
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Creatinine
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Glutathione Peroxidase
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Superoxide Dismutase
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Bilirubin
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Potassium