[Investigation on the gene expression pattern in cervical squamous cell carcinoma of uygur]

Zhonghua Fu Chan Ke Za Zhi. 2003 Jun;38(6):325-7.
[Article in Chinese]

Abstract

Objective: To investigate the differentially expressed gene in cervical squamous cell carcinoma of uygur and normal cervical tissue using gene chip.

Method: Gene chips containing 2,048 human genes were used to investigate the gene expression pattern of 3 samples of cervical cancer.

Result: By applying this gene chip we identified 64 differentially expressed genes in all 3 clinical cervical cancer samples, and we further identified 53 upregulated and 11 downregulated genes for functional analysis.

Conclusion: The analysis of gene expression pattern of tumor based on gene chip can realize high-throughput screening of the genes associated with the cervical cancer.

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / metabolism
  • China
  • Ethnicity
  • Female
  • Gene Expression
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic
  • Genetic Markers / genetics
  • Humans
  • Oligonucleotide Array Sequence Analysis*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / metabolism

Substances

  • Genetic Markers