Abstract
Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.
MeSH terms
-
Anti-HIV Agents / chemical synthesis*
-
Anti-HIV Agents / chemistry*
-
Anti-HIV Agents / pharmacology
-
Anti-HIV Agents / toxicity
-
Cell Death / drug effects
-
Cell Line
-
Drug Design
-
HIV / drug effects
-
Humans
-
In Vitro Techniques
-
Methods
-
Purine Nucleosides / chemical synthesis*
-
Purine Nucleosides / chemistry*
-
Purine Nucleosides / pharmacology
-
Purine Nucleosides / toxicity
-
Structure-Activity Relationship
Substances
-
Anti-HIV Agents
-
Purine Nucleosides