High plasma levels of 8-methoxypsoralen following bath water delivery in dermatological patients

Skin Pharmacol Appl Skin Physiol. 2003 Sep-Oct;16(5):305-12. doi: 10.1159/000072070.

Abstract

With respect to the clinical advantages known for bath PUVA therapy, it was of interest to compare the plasma levels of 8-methoxypsoralen (8-MOP) in bath therapy with those after oral administration for a better insight into the pharmacokinetics of 8-MOP following different modes of application. Considerable high plasma levels of 8-MOP were observed after bath therapy with interindividual variability. The half-life of plasma 8-MOP was markedly shorter after bath PUVA than after oral application. The pharmacokinetic profile of 8-MOP differs according to the mode of application.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Area Under Curve
  • Baths*
  • Biological Availability
  • Female
  • Half-Life
  • Humans
  • Male
  • Methoxsalen / administration & dosage*
  • Methoxsalen / blood*
  • Methoxsalen / pharmacokinetics
  • Middle Aged
  • PUVA Therapy*
  • Photosensitizing Agents / administration & dosage*
  • Photosensitizing Agents / blood*
  • Photosensitizing Agents / pharmacokinetics
  • Skin Absorption
  • Skin Diseases / drug therapy
  • Skin Diseases / metabolism
  • Time Factors
  • Water

Substances

  • Photosensitizing Agents
  • Water
  • Methoxsalen