The role of lipid peroxidation in varicose disease (VD) was studied and clinically substantiated in case of 32 patients with a compensated derangement of the regional phlebohemodynamics. An oxidant-antioxidant misbalance was detected, which displayed itself through a higher level of oxiradicals in the blood plasma as well as through a reduced general antioxidant activity in erythrocytes and a reduced level of enzymes, i.e. superoxide dismutase and catalase, by 40% as compared to the control values in healthy persons. The study results point at an important role of the oxidative stress developing in the capillary angiogenesis and varicose transformation of the surface veins in the legs at a muscle load in the vertical position, if there is constitutive insufficiency of the anti-oxidant protection.