A false-positive ventilation perfusion (V/Q) scan in a patient with a transplanted lung and secondary pulmonary artery stenosis is reported. The patient was examined for tachypnea and shortness of breath after single lung transplantation. A V/Q scan revealed multiple perfusion defects in the transplanted lung, with no corresponding ventilation defects. A pulmonary angiogram revealed pulmonary artery stenosis and no pulmonary emboli. The authors describe a false-positive V/Q scan in a patient after lung transplantation.