Relation between rheological properties and structural changes in monolayers of model lung surfactant under compression

Biophys Chem. 2003 Jul 1;104(3):633-42. doi: 10.1016/s0301-4622(03)00124-8.

Abstract

rSP-C surfactant monolayers spread on a native physiological model substrate show two plateau regions in the pi/A-isotherm. The first corresponds to the main phase transition in the monolayer from a LE to a LC phase. Its course is non-horizontal because of the complex composition of the lung surfactant. The second plateau, which is much more pronounced, cannot be attributed to a change of the phase state. Brewster angle microscopy images taken in this region show a sharp apparent decrease of the aggregation degree from the LE to the LC state. This process can be considered as a change in the monolayer orientation relative to the direction of the propagated light. Such a change can be the result of monolayer folding and formation of a thicker layer, which is supported by results of rheological measurements. The dilatation elasticity obtained from oscillating barrier and longitudinal wave measurements reveals a pure elastic behaviour with a steep increase in the second plateau region. Because of the insolubility of the pure lipid components, a possible explanation is squeezing protein components of rSP-C or its complexes with lipids out of the monolayer into the bulk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1,2-Dipalmitoylphosphatidylcholine / chemistry
  • Membranes, Artificial
  • Palmitic Acids / chemistry
  • Phase Transition*
  • Phosphatidylglycerols / chemistry
  • Pressure
  • Pulmonary Surfactant-Associated Protein C / chemistry
  • Pulmonary Surfactants / chemistry*
  • Recombinant Proteins / chemistry
  • Rheology*
  • Surface Properties

Substances

  • Membranes, Artificial
  • Palmitic Acids
  • Phosphatidylglycerols
  • Pulmonary Surfactant-Associated Protein C
  • Pulmonary Surfactants
  • Recombinant Proteins
  • 1,2-Dipalmitoylphosphatidylcholine