Abstract
We previously demonstrated the excellent protective efficacy of DNA priming followed by Gag-expressing Sendai virus (SeV) boosting (DNA prime/SeV-Gag boost vaccine) against a pathogenic simian-human immunodeficiency virus (SHIV89.6PD) infection in macaques. Here we show that we established a practical, safer AIDS vaccine protocol, a single DNA priming followed by a single booster with a recently developed replication-defective F deletion SeV-expressing Gag, and show its protective efficacy against SHIV89.6PD infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines / administration & dosage*
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AIDS Vaccines / genetics
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / prevention & control
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Animals
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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DNA, Viral / administration & dosage*
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DNA, Viral / genetics
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Defective Viruses / genetics
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Disease Models, Animal
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Genes, gag
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Genetic Vectors
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Humans
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Immunization, Secondary
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Macaca fascicularis
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Macaca mulatta
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SAIDS Vaccines / administration & dosage
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SAIDS Vaccines / genetics
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Sendai virus / genetics
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / prevention & control
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Vaccines, DNA / administration & dosage*
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Vaccines, DNA / genetics
Substances
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AIDS Vaccines
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DNA, Viral
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SAIDS Vaccines
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Vaccines, DNA