Neuroendocrine tumors of the pancreas

Surg Endosc. 2003 Oct;17(10):1658-62. doi: 10.1007/s00464-002-9268-x. Epub 2003 Aug 15.

Abstract

Background: The benefits of associating magnetic resonance imaging (MRI) and laparoscopy for localizing and treating neuroendocrine pancreatic tumors (NEPTs) have been poorly documented.

Methods: In a retrospective study, eight patients with a mean age of 48 years were operated on for a NEPT. MRI was used to localize the lesions. In all patients a laparoscopic resection was carried out. Laparoscopic ultrasonography (LUS) was used during most operations.

Results: The tumor was clearly localized by MRI in seven patients, and LUS showed the lesion in another patient whose preoperative MRI had been unsuitable. Three enucleations, three spleen-preserving caudal pancreatectomies, and two caudal pancreatectomies with splenectomy were carried out. There were no conversions and the mean operating time was 260 min, with a mean blood loss of 180 ml. The mean hospital stay was 7 days. There were no minor nor major complications during the hospitalization period. However, a pancreatic abscess was diagnosed in one patient 1 month later, requiring an urgent laparotomy.

Conclusion: MRI as well as LUS are indeed suitable techniques to localize NEPTs. Moreover, the minimally invasive approach ensured an adequate treatment with a more comfortable and short postoperative recovery.

Publication types

  • Clinical Trial
  • Validation Study

MeSH terms

  • Adult
  • Aged
  • Chemotherapy, Adjuvant
  • Child
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Gastrinoma / diagnosis
  • Gastrinoma / secondary
  • Gastrinoma / surgery
  • Humans
  • Hypoglycemia / etiology
  • Insulinoma / complications
  • Insulinoma / diagnosis
  • Insulinoma / surgery
  • Laparoscopy
  • Length of Stay
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Monitoring, Intraoperative
  • Multiple Endocrine Neoplasia Type 1 / diagnosis
  • Multiple Endocrine Neoplasia Type 1 / surgery
  • Neuroendocrine Tumors / diagnosis
  • Neuroendocrine Tumors / secondary
  • Neuroendocrine Tumors / surgery
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / surgery*
  • Preoperative Care
  • Somatostatin / analogs & derivatives
  • Splenectomy / methods
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Somatostatin