Mapping of viral RNA sequences required for assembly of peanut clump virus particles

J Gen Virol. 2003 Sep;84(Pt 9):2585-2594. doi: 10.1099/vir.0.19247-0.

Abstract

RNA sequences required for assembly into rod-shaped virions of RNA-1 and RNA-2 of Peanut clump virus (PCV) were mapped by testing the ability of different RNA-1 and -2 deletion mutants to be encapsidated in vivo in an RNase-resistant form. Encapsidation of RNA-1 was found to require a sequence domain in the 5'-proximal part of the P15 gene, the 3'-proximal gene of RNA-1. On the other hand, the subgenomic RNA which encodes P15 was not encapsidated, suggesting that other features of RNA-1 are important as well. Two sequences which could drive encapsidation of RNA-2 deletion mutants were located. One was in the 5'-proximal coat protein gene and the other in the P14 gene near the RNA 3' terminus. There were no obvious sequence homologies between the different assembly initiation sequences.

MeSH terms

  • Cell Cycle Proteins*
  • Cyclin-Dependent Kinase Inhibitor p15
  • Gene Deletion
  • Nucleotide Mapping
  • Plant Viruses / physiology*
  • RNA Viruses / physiology*
  • RNA, Viral / genetics
  • Sequence Analysis
  • Transcription Factors / genetics
  • Tumor Suppressor Proteins*
  • Viral Proteins / analysis
  • Viral Proteins / genetics
  • Virus Assembly / genetics*

Substances

  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p15
  • RNA, Viral
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Viral Proteins