Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer

Koji Matsumoto; Toshiharu Yasugi; Shunsuke Nakagawa; Mitsuo Okubo; Ranko Hirata; Hiroo Maeda; Hiroyuki Yoshikawa; Yuji Taketani

doi:10.1002/ijc.11332

Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer

Int J Cancer. 2003 Oct 10;106(6):919-22. doi: 10.1002/ijc.11332.

Authors

Koji Matsumoto¹, Toshiharu Yasugi, Shunsuke Nakagawa, Mitsuo Okubo, Ranko Hirata, Hiroo Maeda, Hiroyuki Yoshikawa, Yuji Taketani

Affiliation

¹ Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan. [email protected]

PMID: 12918070
DOI: 10.1002/ijc.11332

Abstract

The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma in Situ / epidemiology
Carcinoma in Situ / metabolism
Carcinoma in Situ / virology
Case-Control Studies
DNA, Viral / genetics
Female
Genes, MHC Class II*
Genotype
Humans
Japan / epidemiology
Mutation / genetics*
Neoplasm Invasiveness
Oncogene Proteins, Viral / classification
Oncogene Proteins, Viral / genetics*
Papillomaviridae / classification
Papillomaviridae / genetics*
Papillomavirus Infections / complications
Papillomavirus Infections / virology
Polymorphism, Genetic*
Repressor Proteins*
Risk Factors
T-Lymphocytes, Cytotoxic / immunology
Tumor Virus Infections / complications
Tumor Virus Infections / virology
Uterine Cervical Dysplasia / epidemiology
Uterine Cervical Dysplasia / metabolism
Uterine Cervical Dysplasia / virology*
Uterine Cervical Neoplasms / epidemiology
Uterine Cervical Neoplasms / metabolism
Uterine Cervical Neoplasms / virology*

Substances

DNA, Viral
E6 protein, Human papillomavirus type 16
Oncogene Proteins, Viral
Repressor Proteins