Photochemical access to tetra- and pentacyclic terpene-like products from R-(+)-sclareolide

J Org Chem. 2003 Aug 22;68(17):6611-8. doi: 10.1021/jo034177y.

Abstract

Fused tetracyclic oxetanes 4, highly substituted cyclobutenes 6, and the pentacyclic derivatives 7 and 8 were obtained by irradiation of derivatives 3 that were prepared from commercial R-(+)-sclareolide (1) in three steps. Compounds 4 are formed through a Paterno-Büchi reaction, while tricyclic derivatives 6 are the fragmentation products of the first formed oxetanes. In clear contrast, cyclopentenyl and 3-furyl derivatives, 3e and 3f, gave the [2+2] adducts, namely pentacyclic derivatives 7 and 8. All the reported reactions are totally regio- and stereoselective, with the exception of the cyclization of furyl derivative 3f, which gave the mixture of both the crossed (7b) and the right (8) isomers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diterpenes / chemical synthesis*
  • Indicators and Reagents
  • Models, Molecular
  • Molecular Structure
  • Photochemistry
  • Polycyclic Compounds / chemical synthesis*
  • Polycyclic Compounds / chemistry
  • Stereoisomerism
  • Terpenes / chemical synthesis*
  • Terpenes / chemistry

Substances

  • Diterpenes
  • Indicators and Reagents
  • Polycyclic Compounds
  • Terpenes
  • sclareolide