Abstract
The transcription factor FKHR, which is controlled by Akt-PKB signaling, is involved in regulating cell cycle progression and cell death. In this study, the phosphorylation of FKHR was observed in 45 (73.8%) of 61 patients with acute myeloid leukemia (AML). The phosphorylation of Akt-PKB was found to be significantly associated with phospho-FKHR (P<0.001). Patients with phospho-FKHR had a significantly shorter overall survival than those without (P<0.05). In conclusion, the constitutive phosphorylation of FKHR was observed in the majority of AML, and the detection of phospho-FKHR might provide a new tool for identifying AML patients with an unfavorable outcome.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adolescent
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Adult
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Aged
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Blotting, Western
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DNA-Binding Proteins / metabolism*
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Female
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Forkhead Box Protein O1
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Forkhead Transcription Factors
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Gene Expression Regulation, Leukemic*
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Gene Expression Regulation, Neoplastic*
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Genes, Tumor Suppressor
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Glycogen Synthase Kinase 3 / metabolism
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Glycogen Synthase Kinase 3 beta
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Humans
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Leukemia, Myeloid / metabolism*
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Leukemia, Myeloid / pathology
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Male
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Middle Aged
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PTEN Phosphohydrolase
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Phosphoric Monoester Hydrolases / metabolism
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Phosphorylation
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Prognosis
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-akt
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Survival Rate
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Transcription Factors / metabolism*
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Tumor Suppressor Proteins / metabolism
Substances
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DNA-Binding Proteins
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FOXO1 protein, human
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Forkhead Box Protein O1
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Forkhead Transcription Factors
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Proto-Oncogene Proteins
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Transcription Factors
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Tumor Suppressor Proteins
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AKT1 protein, human
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Glycogen Synthase Kinase 3 beta
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt
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Glycogen Synthase Kinase 3
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Phosphoric Monoester Hydrolases
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PTEN Phosphohydrolase
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PTEN protein, human