Abstract
A 13-yr-old female was admitted to our hospital with fever, seizure, and cervical lymphadenopathy. Laboratory data showed pancytopenia, elevation of serum transaminase, lactate dehydrogenase, triglyceride, and ferritin levels. Lymph node biopsy revealed features of Kikuchi's disease and there were signs of histiocytosis and hemophagocytic phenomenon in bone marrow. She recovered after treatment with intravenous immunoglobulin and corticosteroids therapy. Hemophagocytic syndrome can be associated with Kikuchi's disease especially in childhood and seems to have a less aggressive clinical course and better prognosis.
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / therapeutic use
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Biopsy
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Bone Marrow Cells / metabolism
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Bone Marrow Cells / pathology
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Female
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Ferritins / blood
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Histiocytic Necrotizing Lymphadenitis / complications*
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Histiocytic Necrotizing Lymphadenitis / diagnosis*
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Histiocytosis, Non-Langerhans-Cell / complications*
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Histiocytosis, Non-Langerhans-Cell / diagnosis*
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Humans
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Immunoglobulins / metabolism
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Immunoglobulins / therapeutic use
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L-Lactate Dehydrogenase / blood
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Lymph Nodes / pathology
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Lymphatic Diseases / diagnosis
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Necrosis
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Pancytopenia / diagnosis
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Prognosis
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Transaminases / blood
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Triglycerides / blood
Substances
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Adrenal Cortex Hormones
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Immunoglobulins
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Triglycerides
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Ferritins
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L-Lactate Dehydrogenase
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Transaminases