A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice

Paul Denny; Elaine Hopes; Neill Gingles; Karl W Broman; William McPheat; John Morten; Janet Alexander; Peter W Andrew; Steve D M Brown

doi:10.1007/s00335-002-2261-9

A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice

Mamm Genome. 2003 Jul;14(7):448-53. doi: 10.1007/s00335-002-2261-9.

Authors

Paul Denny¹, Elaine Hopes, Neill Gingles, Karl W Broman, William McPheat, John Morten, Janet Alexander, Peter W Andrew, Steve D M Brown

Affiliation

¹ MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK. [email protected]

PMID: 12925893
DOI: 10.1007/s00335-002-2261-9

Abstract

We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Crosses, Genetic
Genetic Linkage
Genetic Predisposition to Disease*
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Pneumococcal Infections / genetics*
Streptococcus pneumoniae*