Deep-seated cerebral lesions have been known to cause various cognitive impairments. In order to study the impact of these lesions on cognitive functioning, in particular on executive functions and spatial abilities, an investigation was carried out on a right-handed patient with lesions in the subcortical structures of the right hemisphere. Findings revealed a complex pattern of neuropsychological impairments that included a memory deficit, neglect and anosognosia. In addition, there was a severe executive function syndrome. Finally, observations show impairments in spatial abilities, usually attributed to right parietal damage. There was no obvious language deficit. The pattern of deficits was interpreted as a disconnection syndrome.