Fatal interaction between tranylcypromine and imipramine

Eur Psychiatry. 2003 Aug;18(5):264-5. doi: 10.1016/s0924-9338(03)00090-7.

Abstract

This case report describes a patient on tranylcypromine who erroneously received a single dose of imipramine and subsequently developed a fatal serotonin syndrome. Both the clinical features and the pathophysiology of the serotonin syndrome are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic Uptake Inhibitors / adverse effects*
  • Adrenergic Uptake Inhibitors / therapeutic use
  • Anti-Anxiety Agents / adverse effects*
  • Anti-Anxiety Agents / therapeutic use
  • Depressive Disorder / drug therapy
  • Drug Interactions
  • Fatal Outcome
  • Humans
  • Imipramine / adverse effects*
  • Imipramine / therapeutic use
  • Male
  • Middle Aged
  • Serotonin Syndrome / chemically induced*
  • Tranylcypromine / adverse effects*
  • Tranylcypromine / therapeutic use

Substances

  • Adrenergic Uptake Inhibitors
  • Anti-Anxiety Agents
  • Tranylcypromine
  • Imipramine