Abstract
A novel series of mono and bisnaphthalimides was synthesized and their antiproliferative activities were evaluated against three tumor cell lines. Bisnaphthalimides 3 and 4, bearing a pyrazine ring fused to the naphthalimide system, showed activities in the order of 10(-8) microM, similar to elinafide. DNA binding properties and the ability to induce DNA damage were studied for some of the most active compounds.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Cell Division / drug effects
-
Cell Line, Tumor
-
Comet Assay
-
DNA / chemistry*
-
DNA Damage
-
Humans
-
Intercalating Agents / chemical synthesis
-
Intercalating Agents / pharmacology
-
Naphthalenes / chemical synthesis*
-
Naphthalenes / chemistry
-
Naphthalenes / pharmacology*
-
Structure-Activity Relationship
-
Topoisomerase I Inhibitors
-
Topoisomerase II Inhibitors
Substances
-
Antineoplastic Agents
-
Intercalating Agents
-
Naphthalenes
-
Topoisomerase I Inhibitors
-
Topoisomerase II Inhibitors
-
DNA