Abstract
Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphotericin B / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Candida albicans / drug effects*
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Drug Resistance, Microbial
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Fatty Acids, Monounsaturated / chemistry
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Fatty Acids, Monounsaturated / isolation & purification*
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Fatty Acids, Monounsaturated / pharmacology
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Fluconazole / pharmacology
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Gas Chromatography-Mass Spectrometry
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Methylation
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Microbial Sensitivity Tests
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Molecular Structure
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Peru
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Plant Roots / chemistry
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Sphingolipids
Substances
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6-nonadecynoic acid
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6-octadecynoic acid
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Antifungal Agents
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Fatty Acids, Monounsaturated
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Sphingolipids
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Amphotericin B
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Fluconazole