To elucidate the molecular pathogenesis of nasopharyngeal carcinoma, the information of genes and literature related to nasopharyngeal carcinoma were enquired. Using Microsoft Access 2000, a simple database was established, which included the genes and literature related to nasopharyngeal carcinoma. According to the information of genes and literature, the molecular pathogenesis and the signal transduction pathway of nasopharyngeal carcinoma were preliminarily described in this paper.