Abstract
Two historical cohorts (1993-1994 and 2001) of preterm infants ventilated for respiratory distress syndrome were compared. Dexamethasone administration fell from 22% to 6%. Chronic lung disease in survivors rose slightly from 13% to 17%, and mortality fell from 21% to 15% (other causes). The effect of restriction of dexamethasone use on chronic lung disease and mortality remains to be seen.
Publication types
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Clinical Trial
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Birth Weight
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Cohort Studies
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Dexamethasone / therapeutic use*
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Gestational Age
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Glucocorticoids / therapeutic use*
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Humans
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Incidence
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Infant Mortality
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Infant, Newborn
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Infant, Premature, Diseases / drug therapy
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Infant, Premature, Diseases / mortality
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Infant, Premature, Diseases / therapy*
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Israel / epidemiology
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Lung Diseases / chemically induced*
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Respiration, Artificial / methods*
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Respiratory Distress Syndrome, Newborn / drug therapy
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Respiratory Distress Syndrome, Newborn / mortality
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Respiratory Distress Syndrome, Newborn / therapy*
Substances
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Glucocorticoids
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Dexamethasone