Abstract
A 67-year-old man with risperidone-responsive segmental dystonia underwent bilateral deep brain stimulation (DBS) of the globus pallidus internus. Prospectively, the authors assessed the Burke-Fahn-Marsden Dystonia Rating Scale in medication (M) and stimulation (S) "on"/"off" states. With DBS at 9 months, the score improved by 86% to 8.5 in M-"on"/S-"on" and 12.5 in M-"off"/S-"on." Studies of the effects of DBS and concomitant medication may be warranted in selected patients treated by DBS for dystonia.
MeSH terms
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Aged
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Antidepressive Agents / therapeutic use
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Combined Modality Therapy
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Cyclohexanols / therapeutic use
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Depression / chemically induced
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Depression / drug therapy
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Dopamine Antagonists / adverse effects
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Dopamine Antagonists / therapeutic use*
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Dystonic Disorders / drug therapy
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Dystonic Disorders / physiopathology
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Dystonic Disorders / therapy*
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Electric Stimulation Therapy*
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Globus Pallidus / physiopathology*
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Humans
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Male
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Parkinson Disease, Secondary / chemically induced
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Risperidone / adverse effects
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Risperidone / therapeutic use*
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Severity of Illness Index
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Venlafaxine Hydrochloride
Substances
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Antidepressive Agents
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Cyclohexanols
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Dopamine Antagonists
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Venlafaxine Hydrochloride
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Risperidone