Objective: To report a case of blastic natural killer cell leukemia with an aggressive clinical course.
Methods: The characteristics of blastic NK cell leukemia and its treatment were discussed with review of literatures.
Results: After combination chemotherapy and spinal cord segmental radiotherapy, the patient entered hematological remission, but the extramedullary lesion remained unchanged.
Conclusion: Blastic NK cell leukemia has an aggressive clinical course with poor response to treatment and unfavorable prognosis.