Abstract
We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 microg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 (median, 0.46).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Animals
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Antifungal Agents / administration & dosage
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Antifungal Agents / blood
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Antifungal Agents / cerebrospinal fluid
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Antifungal Agents / metabolism
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Brain / metabolism*
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Brain / pathology*
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Brain Chemistry
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Child
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Child, Preschool
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Drug Administration Schedule
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Female
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Guinea Pigs
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Humans
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Immunocompromised Host*
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Male
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Middle Aged
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Mycoses / drug therapy*
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Pyrimidines / administration & dosage
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Pyrimidines / blood
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Pyrimidines / cerebrospinal fluid*
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Triazoles / administration & dosage
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Triazoles / blood
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Triazoles / cerebrospinal fluid*
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Voriconazole