Abstract
Bio-guided fractionation of an extract from Tanacetum parthenium showing activity as mitotic blocker allowed the isolation and identification of santin 3, jaceidin 2 and centaureidin 1. The latter two closely related flavonols, which, to the best of our knowledge, are isolated here together for the first time, form a mixture difficult to resolve and which is probably the reason for the confusion in the literature regarding their occurrence. Centaureidin 1 had an IC50 of 1 microM while jaceidin 2 and santin 3 were 200 times less active.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Chemical Fractionation / methods
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Flavonols / chemistry
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Flavonols / isolation & purification*
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Flavonols / pharmacology*
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Inhibitory Concentration 50
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Mitosis / drug effects
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Plant Extracts / chemistry
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Tanacetum parthenium / chemistry*
Substances
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Antineoplastic Agents
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Flavonoids
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Flavonols
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Plant Extracts
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santin
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centaureidin