Abstract
We hypothesized that the association of high sensitivity C-reactive protein (CRP) with urinary albumin excretion (UAE) is predominately mediated through its correlation with the metabolic syndrome. Serum CRP and urine albumin:creatinine ratios (ACR) from 720 preventive cardiology patients were analyzed to estimate age- and gender-adjusted relative risk of high CRP and metabolic syndrome for high ACR. These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction.
MeSH terms
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Age Factors
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Albuminuria / etiology
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Albuminuria / urine*
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Biomarkers / blood
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Biomarkers / urine
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C-Reactive Protein / metabolism*
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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Cohort Studies
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Coronary Disease / etiology
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Coronary Disease / prevention & control
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Creatinine / urine*
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Diabetes Complications
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Female
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Humans
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Hyperlipidemias / blood
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Hyperlipidemias / complications
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Hypertension / complications
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Logistic Models
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Male
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Metabolic Syndrome / blood*
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Metabolic Syndrome / complications
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Metabolic Syndrome / diagnosis
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Metabolic Syndrome / urine*
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Middle Aged
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Risk
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Risk Factors
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Sensitivity and Specificity
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Serum Albumin
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Sex Characteristics
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Smoking / adverse effects
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Triglycerides / blood
Substances
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Biomarkers
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Cholesterol, HDL
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Cholesterol, LDL
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Serum Albumin
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Triglycerides
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C-Reactive Protein
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Creatinine