Abstract
The enantioselective synthesis of a potent Maxi-K potassium channel opener (BMS-204352) mediated by N-fluoroammonium salts of cinchona alkaloids is described. Two synthetic pathways were evaluated. An ee as high as 88% was achieved (>99% after a single recrystallisation).
MeSH terms
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Cinchona Alkaloids / chemistry*
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Hydrocarbons, Fluorinated / chemistry
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Indoles / chemical synthesis*
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Quaternary Ammonium Compounds / chemistry
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Stereoisomerism
Substances
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BMS204352
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Cinchona Alkaloids
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Hydrocarbons, Fluorinated
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Indoles
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Quaternary Ammonium Compounds