Abstract
Bioassay-directed fractionation of a CH(2)Cl(2)-MeOH (1:1) extract of the aerial parts of Flourensia cernua led to the isolation of three phytotoxic compounds, namely, dehydroflourensic acid (1), flourensadiol (2) and methyl orsellinate (3). Dehydroflourensic acid is a new natural product whose structure was established by spectral means. In addition, the known flavonoid ermanin and seven hitherto unknown gamma-lactones were obtained, these being tetracosan-4-olide, pentacosan-4-olide, hexacosan-4-olide, heptacosan-4-olide, octacosan-4-olide, nonacosan-4-olide, and triacontan-4-olide. Compounds 1-3 caused significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interacted with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
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Amaranthus / drug effects*
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Amaranthus / growth & development
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Animals
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Asteraceae / chemistry*
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Calmodulin / antagonists & inhibitors
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Cattle
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Cyclic Nucleotide Phosphodiesterases, Type 1
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Echinochloa / drug effects*
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Echinochloa / growth & development
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology*
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Gas Chromatography-Mass Spectrometry
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Inhibitory Concentration 50
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Molecular Structure
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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Plants, Toxic / chemistry
Substances
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Calmodulin
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Enzyme Inhibitors
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Plant Extracts
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 1